MUSCAT CHEMICAL TAG::
monothioglycerol ar 98 is a viscous colorless to slightly yellowish hygroscopic liquid. It smells a bit sulfurous.
The present invention relates to processes for purifying high-quality recombinant Plasmodium falciparum circumsporozoite protein at high yields. This process provides rCSP at high yields without the need for denaturing and refolding the protein. The present invention overcomes obstacles previously encountered in the field, including dimerization, aggregation, and N-terminal degradation of rCSP.
Standard dosing regimen: initial intravenous bolus dose of 6.5 mg/kg ... are highly protein bound (approximately 98%), primarily to albumin.